Compulsive eating and weight gain related to dopamine agonist use
Identifieur interne : 003518 ( Main/Exploration ); précédent : 003517; suivant : 003519Compulsive eating and weight gain related to dopamine agonist use
Auteurs : Melissa J. Nirenberg [États-Unis] ; Cheryl Waters [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Compulsive Behavior (chemically induced), Compulsive Behavior (physiopathology), Dopamine Agonists (adverse effects), Dopamine agonist, Eating Disorders (chemically induced), Eating Disorders (physiopathology), Female, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Weight Gain (drug effects), Weight gain, binge, compulsive eating, dopamine agonist, weight gain.
- MESH :
- chemical , adverse effects : Dopamine Agonists.
- chemically induced : Compulsive Behavior, Eating Disorders.
- drug effects : Weight Gain.
- drug therapy : Parkinson Disease.
- physiopathology : Compulsive Behavior, Eating Disorders.
- Female, Humans, Male, Middle Aged.
Abstract
Dopamine agonists have been implicated in causing compulsive behaviors in patients with Parkinson's disease (PD). These have included gambling, hypersexuality, hobbyism, and other repetitive, purposeless behaviors (“punding”). In this report, we describe 7 patients in whom compulsive eating developed in the context of pramipexole use. All of the affected patients had significant, undesired weight gain; 4 had other comorbid compulsive behaviors. In the 5 patients who lowered the dose of pramipexole or discontinued dopamine agonist treatment, the behavior remitted and no further weight gain occurred. Physicians should be aware that compulsive eating resulting in significant weight gain may occur in PD as a side‐effect of dopamine agonist medications such as pramipexole. Given the known risks of the associated weight gain and obesity, further investigation is warranted. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20757
Affiliations:
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Nirenberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Movement Disorders, Department of Neurology, Columbia University Medical Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Movement Disorders, Department of Neurology, Columbia University Medical Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-04">2006-04</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="524">524</biblScope><biblScope unit="page" to="529">529</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">47AAA15FC13290DBB65351837B9A150C1079A72B</idno><idno type="DOI">10.1002/mds.20757</idno><idno type="ArticleID">MDS20757</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Compulsive Behavior (chemically induced)</term><term>Compulsive Behavior (physiopathology)</term><term>Dopamine Agonists (adverse effects)</term><term>Dopamine agonist</term><term>Eating Disorders (chemically induced)</term><term>Eating Disorders (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Weight Gain (drug effects)</term><term>Weight gain</term><term>binge</term><term>compulsive eating</term><term>dopamine agonist</term><term>weight gain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Compulsive Behavior</term><term>Eating Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Weight Gain</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Compulsive Behavior</term><term>Eating Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Prise poids</term><term>Stimulant dopaminergique</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine agonists have been implicated in causing compulsive behaviors in patients with Parkinson's disease (PD). These have included gambling, hypersexuality, hobbyism, and other repetitive, purposeless behaviors (“punding”). In this report, we describe 7 patients in whom compulsive eating developed in the context of pramipexole use. All of the affected patients had significant, undesired weight gain; 4 had other comorbid compulsive behaviors. In the 5 patients who lowered the dose of pramipexole or discontinued dopamine agonist treatment, the behavior remitted and no further weight gain occurred. Physicians should be aware that compulsive eating resulting in significant weight gain may occur in PD as a side‐effect of dopamine agonist medications such as pramipexole. Given the known risks of the associated weight gain and obesity, further investigation is warranted. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Nirenberg, Melissa J" sort="Nirenberg, Melissa J" uniqKey="Nirenberg M" first="Melissa J." last="Nirenberg">Melissa J. Nirenberg</name></region><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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